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01 Notice of change of transfer and warrant agent Incorporated by Reference. 1 List of subsidiaries of the Company.

Irwin an irrevocable proxy to vote the 1,740,575 shares of common stock held or controlled by it. The proxy will terminate upon the sale of such shares to any unaffiliated third party. (7) Includes options to purchase 75,000 shares of common stock. (8) Includes options to purchase 325,000 shares of common stock. ITEM 12. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.

During earlier studies it became evi- dent that the metabolism and the excretion kinetics of thiol compounds varied enormously (Brock et al. 1981 b, 1982 b). Therefore the present investigations were designed to establish some of the principles of the detoxifying reactions in relation to some pharmacoki- netic parameters of thiol compounds (Pohl et al. 1981).]